Abstract
Objective To investigate the effect and mechanism of hyperbaric oxygen (HBO) on hypoxic-ischemia brain damage (HIBD)in neonatal rats. Methods Neonatal SD rats were pre-treated by means of hyperbaric oxygen exposure at a pressure of 0.25 MPa for 150 min. Following treatment after 24 hours, HIBD model was developed by the occlusion of left carotid artery, and then the animals were exposed to a mixture of 8% oxygen and 92% nitrogen for 90 min. Assessment of neural stem cells (NSCs) in the brain tissue was made with immunohistochemistry. Observation on the proliferation of neural stem cells in cortex and hippocampus, rate of increase in body weight and cerebral morphology after adulthood was also made following injury. Learning and memory of the animals were determined with labyrinth. Results Proliferation of neural stem cells increased dramatically for the animals in the hyperbaric oxygen group. Significant differences could be noted in development, cerebral morphology, learning and memory, when compared with those of the HIBD animals without HBO treatment. Conclusions Hyperbaric oxygen pre-treatment might have certain protective effect on HIBD in neonatal rats, possibly through the proliferation of NSCs and might also influence cerebral development at later stages. Key words: Hyperbaric oxygen; Neural stem cells; Hypoxia-ischemia brain damage; Brain deuelopment; Learning and memory ability
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