Abstract
Untreated human gamma globulin (Ig), pepsin-treated Ig and purified F (ab') 2 were examined for their protective effects on experimental bacterial infections in mice. All these preparations were similarly effective in protecting mice from death after intraperitoneal administration of Streptococcus pneumoniae NCTC 7465, Escherichia coli 81 or Serratia marscescens OH 942. The protective effect of pepsin-treated Ig decreased significantly when the Ig was absorbed with the bacteria used for infection of mice, suggesting that the protective effect of Ig is due to a specific antibody. Administration of Ig preparations inhibited growth of bacteria in the blood stream of infected animals. In vitro experiments with a macrophage cell line showed that treatment of bacteria with Ig preparations including F (ab') 2 stimulated phagocytic activity of the macrophages.
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Schedule a callMore From: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases
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