Protective effect of guabiju (Myrcianthes pungens (O. Berg) D. Legrand) and red guava (Psidium cattleyanum Sabine) against cisplatin-induced hypercholesterolemia in rats

Cleice Dalla Nora,Erna Vogt De Jong,Simone Hickmann Flôres,Daiane Danelli,Lucéia Fátima Souza,Alessandro De Oliveira Rios

doi:10.1590/s1984-82502014000300006

Abstract

The present study was the first to examine the protective effect and antioxidant potential of two fruits native to the south of Brazil, namely guabiju (Myrcianthes pungens (O. Berg) D. Legrand) and red guava (Psidium cattleyanumSabine), with respect to reducing the effects of cisplatin-induced hypercholesterolemia in male Wistarrats. The cisplatin-treated animals showed high glucose, LDL cholesterol, oxidized LDL cholesterol and total cholesterol levels. These native fruits reversed the increase in these parameters. The fat levels in the liver improved with supplementation with the fruits, and there were no differences in the thiobarbituric acid reactive substances (TBARS), creatinine, urea or HDL cholesterol levels, nor in the weight of the organs analyzed, indicating that the dose used did not affect these markers.

Highlights

Studies have proven that the consumption of fruits is related to a low incidence of chronic degenerative diseases (Ruxton, Gardner, Walker, 2006; Van’t Veer et al, 2000)
In a comparative study of the minerals of different native species, the following were found for red guava, in decreasing order: TABLE I – Physicochemical composition of freeze-dried red guava and guabiju
Pathol., v.34, n.3, p.182-187, 2005. This is the first study of guabiju and red guava fruits in vivo and we recommend inclusion of these fruits in disease-preventing diets

Summary

Introduction

Studies have proven that the consumption of fruits is related to a low incidence of chronic degenerative diseases (Ruxton, Gardner, Walker, 2006; Van’t Veer et al, 2000). The benefits of native and exotic fruits have been reported in various studies. There is no doubt that fruits in. Legrand) are two fruits of the Myrtaceae family, and both are native to the state of Rio Grande do Sul, Brazil. Red guava is a spherical fruit, crowned by persistent sepals and red when ripe, and it has many small seeds surrounded by soft, whitish succulent pulp. It has a very pleasant sweetacid flavor.

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Results

Conclusion