Abstract
Objective To evaluate the radioprotective effects of ginsenoside Rh2 on mice in response to X-ray irradiation.Methods Mice were initially subjected to whole body X-ray irradiation with total doses of 4 Gy at a dose rate of 0.5 Gy/min.Then,the mice were intragastrically administered instantly with 5,10 or 20 mg/kg ginsenoside Rh2.At 24 h post-irradation,the damage to bone marrow cells as well as DNA fragments in peripheral blood leukocytes (PBLs) were assessed by micronucleus (MN) test and comet assay,respectively.The splenic lymphocyte transformation mediated by concanavalin (ConA) and Iipopolysaccharide (LPS) was measured by MTT colorimetric method.Results The present study demonstrated that Ginsenoside Rh2 significantly decreased the DNA damage degree in PBLs and MN formation in bone marrow polychromatic erythrocytes in a concentration dependent manner.Also,the treatment with Ginsenoside Rh2 enhanced the splenic lymphocyte transformation activities.Conclusions The administration of Ginsenoside Rh2 shortly after irradiation is able to prevent the mice from the genotoxicity and immunotoxicity induced by X-rays and,probably,offer a promising strategy for both protection and treatment of radiation injuries. Key words: Ginsenoside Rh2; X-rays; Radiation protection
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
