Abstract
Objective To evaluate the radioprotective effects of ginsenoside Rh2 on mice in response to X-ray irradiation.Methods Mice were initially subjected to whole body X-ray irradiation with total doses of 4 Gy at a dose rate of 0.5 Gy/min.Then,the mice were intragastrically administered instantly with 5,10 or 20 mg/kg ginsenoside Rh2.At 24 h post-irradation,the damage to bone marrow cells as well as DNA fragments in peripheral blood leukocytes (PBLs) were assessed by micronucleus (MN) test and comet assay,respectively.The splenic lymphocyte transformation mediated by concanavalin (ConA) and Iipopolysaccharide (LPS) was measured by MTT colorimetric method.Results The present study demonstrated that Ginsenoside Rh2 significantly decreased the DNA damage degree in PBLs and MN formation in bone marrow polychromatic erythrocytes in a concentration dependent manner.Also,the treatment with Ginsenoside Rh2 enhanced the splenic lymphocyte transformation activities.Conclusions The administration of Ginsenoside Rh2 shortly after irradiation is able to prevent the mice from the genotoxicity and immunotoxicity induced by X-rays and,probably,offer a promising strategy for both protection and treatment of radiation injuries. Key words: Ginsenoside Rh2; X-rays; Radiation protection
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