Abstract
The object of this study was to investigate the functionality of Ginseng (Panax ginseng) leaf extract (GLE) as a cosmeceutical material. We adopted Ultraviolet‐B irradiated hairless mice model to evaluate the protective effect of GLE from UVB‐induced photoaging. Skin photodamage was induced by exposure to gradient doses of UVB (36–144 mJ/cm2, for 10 weeks on alternate days). GO groups were given daily administration of ginseng leaf (0.1% and 0.2% of drinking water, respectively) and GA groups were given topical application of ginseng leaf (0.5 mg/cm2 and 1.0 mg/cm2 skin area) to evaluate dose dependent effect. We observed deep wrinkle, erythema and thick skin on the control hairless mice. UVB irradiation increased the expression of matrix metalloproteases (MMPs), which attacked collagen and elastin fiber cross linkage. After GLE treatment, a considerable recovery from photo‐damage was observed by the treatments. GLE reduced the UVB‐induced activation and expression of MMPs via upregulating tissue inhibitor of metalloproteinase (TIMP). Taken together, these results suggest that the protective effect of GLE on skin photoaging induced by chronic UVB exposure may be due to the inhibition of MMP expression and/or the increased TIMP expression.
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