Abstract
The present investigation was performed in aspirin and pylorus ligation-induced ulcer model in Wistar rats, in which ability of ginger oil to provide gastric protection was studied at two different doses, 0.5 and 1 g/kg po. Gastric protection was evaluated by measuring the ulcer index, serum γ-GTP levels, total acidity of gastric juice and gastric wall mucus thickness. The results obtained in the present study indicated that ginger oil has a protective action against gastric ulcers induced by aspirin plus pylorus ligation in Wistar rats.
Highlights
Peptic ulcer is worldwide problem and its prevalence is quite high in India
Administration of ginger oil in two doses of 0.5 g/kg, p.o. and 1 g/kg, p.o. resulted in significant reduction in serum γ-GTP levels, ulcer index, total acidity and increase in gastric wall mucus thickness
In the standard drug-treated rats, there was a significant decrease in serum γ-GTP levels, ulcer index, total acidity and increase in gastric wall mucus thickness but no significant change was found in volume of gastric juice as compared with aspirin+pylorus ligated rats
Summary
Peptic ulcer is worldwide problem and its prevalence is quite high in India. Several field studies from different parts of our country suggest its occurrence in 4 to 10 per thousand populations. Total acidity was increased but no significant change occurred in volume of gastric juice as compared to CMC+ pylorus ligated rats (i.e. group II rats).
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