Abstract
Lycium barbarum L. (Solanaceae) is widely used in Iraqi Ayurvedic medicine for the treatment of diabetes mellitus. The present investigation was done to evaluate the effects of polysaccharide (galactomannan) from Lycium barbarum L. Fruits (GLBF) on serum blood glucose, serum lipid profile and lipid peroxidation and antioxidant defence system in liver and kidney of alloxan-induced diabetic rats. GLBF was found to be non-toxic at 1000 mg kg-1, as no deaths or hazardous signs were recorded during treatment or the observation period (24 and 72 h) in either control or treated groups of mice. In GLBF (500 mg kg-1), the onset was 4 h, the peak effect was 6 h but the effect waned at 24 h. In the chronic study, repeated administration (once a day for 21 days) of the glibenclamide and GLBF caused a significant reduction in the serum glucose level as compared to the diabetic control group. GLBF (500 mg kg-1) treatment prevented a decrease in the body weight of the diabetic rats. Moreover, the results revealed that GLBF (500 mg kg-1) treatment for 21 days significantly (p
Highlights
Diabetes mellitus, an endocrine disorder is associated with depleted insulin secretions with altered carbohydrate, lipid and protein metabolism
No death or hazardous signs were recorded during treatment or the observation period (24 and 72 h) in either control or treated groups of mice with GLBF (100, 500 and 1000 mg kg−1)
It is concluded that the consumption of GLBF caused a significant reduction in glucose level of alloxan diabetic rats
Summary
An endocrine disorder is associated with depleted insulin secretions with altered carbohydrate, lipid and protein metabolism. Complications such as renal failure, coronary artery, cerebral-vascular disease, neurological complications, blindness, limb amputation, long term damage, dysfunctions, failure of various organs and eventually premature death are associated with chronic hyperglycemia (Lanjhiyana et al, 2011). High levels of free radicals with concurrent decline of antioxidant defense mechanism may lead to damage of cellular organelles and enzymes (Ottaviano et al, 2008). This can culminate in increased lipid peroxidation and development of insulin resistance, which may promote the development of complications of diabetes mellitus (Demozay et al, 2008). The use of oral antidiabetics is limited due to their adverse side effects including hematological, cutaneous and gastrointestinal reactions, hypoglycaemic coma and disturbances of liver and
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