Abstract
Objective: To evaluate the protective effect of ethanolic extract of dried seeds of Coriandrum sativum L. (C.sativum) in acetic acid-induced ulcerative colitis in rats.Methods: Male Wistar rats were divided into various treatment groups (n=5). The animals were administered with 2ml of acetic acid (4% v/v) via intrarectal route to induce colitis. Prednisolone (2mg/kg) was used as a standard drug and C.sativum was administered at a dose of 100 and 300 mg/kg p.o. Macroscopic scoring, colon weight to length ratio, colonic superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), lipid peroxidation (LPO), myeloperoxidase (MPO) levels and histopathological changes were recorded after the treatment regimen of 11 days.Results: Intrarectal instillation of acetic acid caused significant (P<0.05) increase in colon weight to length ratio, LPO, and MPO levels; and significant (P<0.05) decrease in the levels of SOD, CAT and GSH levels. Pretreatment with C.sativum (100, 300 mg/kg, p.o.) exhibited significant (P<0.05) reversal of all the above biochemical parameters and significantly reversed the histopathological changes induced by acetic acid treatment.Conclusion: The present investigation demonstrates the potent therapeutic value of C.sativum (100, 300 mg/kg, p.o.) in the amelioration of experimental colitis in rats. The beneficial effect of C.sativum could be attributed to its antioxidant effect.
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