Abstract
Purpose : To investigate the ameliorative effect of ethanolic extract of Carica papaya leaves in alloxan - induced diabetic rats. Methods : Rats were randomly divided into five groups of eight animals each. Group A (control) comprised normal healthy animals which were orally administered 1.0 ml of distilled water daily for 21 days while groups B – E consisted of alloxan-induced diabetic rats. Group B comprised diabetic untreated rats, and groups C and D received 1.0 ml of 250 mg/kg and 500 mg/kg body weight of the extract, respectively. Group E received 300 mg/kg of metformin. Results : Administration of the extract to the diabetic rats significantly reduced (p < 0.05) glucose level (123.50 mg/dl), total cholesterol (TC), triglyceride (1.24 mg/dl) and low density lipoprotein cholesterol (LDL-C), while significantly increasing (p < 0.05) high density lipoprotein cholesterol (HDL-C) and total protein level (66.51 g/dl) compared to the diabetic untreated rats. The extract also significantly decreased (p < 0.05) the concentration of serum urea (12.35 mg/dl), creatinine, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) of the diabetic rats. Conclusion : The ethanol leaf extract of Carica papaya ameliorates metabolic disorder caused by diabetes in rats. Keywords : Diabetes, Carica papaya , Glucose, Lipid profile, Alloxan monohydrate
Highlights
Diabetes mellitus is a metabolic disorder associated with chronic hyperglycaemia and imbalance of carbohydrate, protein and fat metabolism
The significant increase (p < 0.05) witnessed in total cholesterol level of the diabetic untreated rats compared to the control was significantly reduced (p < 0.05) by the 250 mg/kg body weight of the extract
Administration of the extract significantly increased (p < 0.05) the high density lipoprotein cholesterol (HDL-C) concentration of the diabetic rats compared to the diabetic untreated ones
Summary
Diabetes mellitus is a metabolic disorder associated with chronic hyperglycaemia and imbalance of carbohydrate, protein and fat metabolism. It is characterized by deficiency in insulin secretion and/or insulin action [1]. Diabetes mellitus constitutes a major health and socioeconomic burden for diabetic patients and the healthcare providers. According to report by the World Health Organization (WHO), there were 150 million diabetic patients worldwide by the year 2000, with a projection of 221 million people in 2010 and 300 million in 2015 [3]. The International Diabetes Federation (IDF) reported that diabetic population in Africa is 19.8 million and this is expected to increase to 41.5 million in 2035 [1]
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