Abstract
Aqueous and ethanol extracts of Carica papaya has been evaluated for its hepatoprotective activity in rats. The aqueous and ethanol extracts of C. papaya showed significant hepatoprotection against carbon tetrachloride induced hepatotoxicity. The protective activity was evaluated by using biochemical parameters such as serum bilirubin, serum alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase. The histopathological changes of liver were compared with control.
Highlights
Despite tremendous development in the field of medical science, liver diseases are still the threatening problems to our health
The present study was chosen to investigate the effect of dried fruits of C. papaya on hepatotoxicity (Rajkapoor et al, 2002) with giving emphasis on comparative efficacy of aqueous and ethanol extracts of C. papaya used in both studies which may be helpful for determination of active principle in future
Experiment I resulted in elevated level of biochemical parameters in CCl4-treated group indicating the hepatotoxic effects of carbon tetrachloride
Summary
Despite tremendous development in the field of medical science, liver diseases are still the threatening problems to our health. Virus related liver diseases are important causes of morbidity and mortality in Bangladesh. HBV and HCV are emerging as important etiological factor for such disease in Bangladesh (Ahmed, 2005). C. papaya is commonly cultivated and planted in Bangladesh for its edible fruits, grows naturally in Waste Lands. Fruit of C. papaya is a rich source of vitamin C. It contains vitamin E, pectin and carotinoids. To combat the increasing liver diseases in Bangladesh, it is essential to explore our plant resources to develop an effective hepatoprotective agent for the benefit of our people. The present study was chosen to investigate the effect of dried fruits of C. papaya on hepatotoxicity (Rajkapoor et al, 2002) with giving emphasis on comparative efficacy of aqueous and ethanol extracts of C. papaya used in both studies which may be helpful for determination of active principle in future
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