Abstract
lonizing radiation can induce oxidative stress through generation of reactive oxygen species (ROS) resulting in cell damage and cell death. We have investigated the radioprotective effect of dieckol, which was isolated from Ecklonia cava, against oxidative stress induced cell damage in Chinese hamster lung fibroblast (V79-4) cells. Dieckol was found to reduce the intracellular ROS generated by γ-ray radiation. Moreover, dieckol also protected the cell viability damaged by the radiation through inhibition of apoptosis. Irradiated cells with dieckol treatment reduced. the expression of phospho histone H2A.X (a marker for DNA strand breakage) and the activation of caspase 9, which were induced by radiation. These results suggest that dieckol protected γ-ray radiation induced apoptosis of V79-4 lung fibroblast cells by inhibiting ROS generation.
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