Abstract
<p>In this study, we investigated the antioxidant capacity of persimmon wine (PW) and dealcoholized persimmon wine (DPW). Both PW and DPW showed radical scavenging activity in the DPPH (1-diphenyl-2-picrylhydrazyl) assay. We next analyzed the phenolic content and major compounds present in PW using high-performance liquid chromatography (HPLC). Phenolic compounds, including gallic acid, catechin, and epicatechin, were found in PW. Gallic acid was the most abundant phenolic compound (157.5 µg/ml) in PW. In addition, the protective effects of DPW and gallic acid against H<sub>2</sub>O<sub>2</sub>-induced cell injury in H9c2 cardiomyocytes were investigated. Pretreatment with DPW or gallic acid strongly inhibited H<sub>2</sub>O<sub>2</sub>-induced cell death in a dose-dependent manner. These results suggested that PW and its major phenolic component, gallic acid, were effective inhibitors of oxidative stress and oxidative stress-induced cardiomyocyte injury.</p>
Highlights
IntroductionPersimmon fruit showed some lipid lowering effects in animal models (Matsumoto, Watanabe, Ohya, & Yokoyama, 2006)
Persimmon is widely grown in oriental countries, such as China, Japan, and Korea
These results demonstrated that persimmon wine (PW) had antioxidant effects, and suggested that gallic acid may play an important role in these effects
Summary
Persimmon fruit showed some lipid lowering effects in animal models (Matsumoto, Watanabe, Ohya, & Yokoyama, 2006). It is abundant in nutrients, including vitamins A, B, and C; carotenoids; glucose, and fructose. Persimmon contains other active compounds, such as polyphenols, which have been reported to have protective effects against oxidative stress, and exerted benefits on diabetes, obesity, cardiovascular disease, and even cancer (Matsumoto, Watanabe, Ohya, & Yokoyama, 2006; Wojcik, Burzynska-Pedziwiatr, & Wozniak, 2010). A number of studies have suggested that antioxidants have protective effects on ischemia-reperfusion-induced cell death. Dealcoholized persimmon wine (DPW) was used to investigate cardioprotection in H9c2 cells because the alcohol in PW can affect the cell system and was not added directly to the cells
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