Abstract
This study used an experimental method in the laboratory with a randomized design with five treatments and six repetitions. The parameters examined were cholinesterase (ChE), Aspartate Aminotransferase (AST), and serum Alanine Aminotransferase (ALT) of blood in the first and second treatment stages. Data were analyzed using factorial ANOVA test and LSD multiple comparison test with 95% confidence level with R software version 3.6.2. Wistar rats were given chlorpyrifos (6.75, 13.5, 27, 54) mg/kg BW/day orally once a day for 28 consecutive days, then further intervention with curcumin (27, 54, 108 and 216) mg/kg BW/day once a day for 14 consecutive days. A significant increase in ChE activity and a significant decrease in AST and ALT activity. This study shows that curcumin from Curcuma longa Linn rhizome extract provides a protective effect against chlorpyrifos poisoning in Wistar rats.
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