Abstract
The present study was carried out to evaluate the protective effects of curcumin on Cyclophosphamide-induced deleterious lipid profile in rats. Experimental rats were randomly divided into four groups of five rats each. Group 1: served as the control rats, Group 2: was administered daily curcumin at a dose (150 mg/kg b.wt). Group 3: a single dose of cyclophosphamide (150 mg/kg, i.p.) intraperitoneal injection, Group 4: was injected with cyclophosphamide + curcumin along the experimental period (30 days). The results refer to a significant elevation of lipid parameters (cholesterol, triglyceride and LDL-C) while a significant decrease in some other parameters (HDL-C). On the 30 days in rats injected intraperitoneal with cyclophosphamide as compared to the control groups. The administration of the curcumin has beneficial and decrease side effects against the deleterious changes of CCl4. Concluded that supplementation of curcumin reverted these abnormalities in the lipid levels to near normalcy after cyclophosphamide administration.
Highlights
Disorders have been identified as a common side effect of treatment with chemotherapeutic agents such as cyclophosphamide, 5-fluorouracil, methotrexate, and doxorubicin (Schagen and Wefel 2013).Cyclophosphamide is an alkylating chemotherapeutic agent, and it has extensive use for adjuvant or neoadjuvant purposes in the treatment of hematological malignancies, neuroblastoma, retinoblastoma, rhabdomyosarcoma, breast, lung, endometrium and ovarian cancers
The groups treated with cyclophosphamide recorded significantly (p < 0.05) elevated serum cholesterol, triglyceride and LDL-C levels while a significant decrease in some other parameters (HDL-C) when compared to the control group after 30 days
Rats treated with cyclophosphamide + curcumin observed a significant decrease (p < 0.05) in serum cholesterol, triglyceride and LDL-C levels and a significant increase in some other cyclophosphamide groups after 30 days. parameters (HDL-C) when compared with As shown in Tables (1, 2, 3 and 4)
Summary
Disorders have been identified as a common side effect of treatment with chemotherapeutic agents such as cyclophosphamide, 5-fluorouracil, methotrexate, and doxorubicin (Schagen and Wefel 2013). Cyclophosphamide is an alkylating chemotherapeutic agent, and it has extensive use for adjuvant or neoadjuvant purposes in the treatment of hematological malignancies, neuroblastoma, retinoblastoma, rhabdomyosarcoma, breast, lung, endometrium and ovarian cancers. The use of natural antioxidants in order to minimize the side effects of chemotherapeutic agents such as Cyclophosphamide has increased in recent years. Its homeland is East India and is defined as “the queen of spices”. It includes natural polyphenol derivatives, gives a yellow color to natural turmeric plants, has antioxidant, anti-inflammatory, and apoptosis-inducing features and naturally inhibits cancer cell proliferation (Kreutz et al, 2018)
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