Protective Effect of Curcumin Against Adverse Effects of Meloxicam in Rats

Abstract

The aim of the present study was to determine the adverse effects of meloxicam on lipid profile, glucose profile andhematology as well as the protective effect of curcumin in rats. Thirty-six male Wister albino rats were randomly dividedinto main four groups; Group (1): control (administered saline only 0.5 ml); Group (2): meloxicam was administeredintraperitoneally at level of 5.8 mg/kg body weight for 15 days; Group (3): curcumin extract was administered orally atlevel of 200 mg/kg body weight for 15 days; Group (4): were administered meloxicam intraperitoneally with oraladministration of curcumin extract for 15 days. The findings revealed that there were significant increase in serumcholesterol level and serum triglycerides level of rat given meloxicam. There were significant decrease in serumcholesterol level and serum triglycerides of rats administered meloxicam with curcumin group. There was a significantincrease in serum glucose level of rat given meloxicam. There was significant decrease in serum glucose level ofmeloxicam with curcumin group compared to meloxicam group. There was alteration in hematological parameters of ratgiven meloxicam. On the contrary, there was an improvement in hematological tests of meloxicam with curcumin groupand improvement of histopathological study compared to meloxicam. On conclusion, administration of meloxicamintraperitoneally 5.8 mg/kg body weight resulted in impairment in lipid profile, glucose profile and hematologicalparameters and these impairments could be improved by curcumin administration.