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Abstract
Pain, paraesthesia, sensory loss, and associated high morbidity and mortality are typically characterized by diabetic neuropathy (DN). Curculigo orchioides (CO) is a herbal medicine that is rich in flavonoids, glycosides, and polyphenols which are known for potential antioxidant activity. Moreover, the anti-hyperglycemic potential of CO paved the way for pharmacological investigation in the treatment of diabetic complications since the regulation of hyperglycemia is considered as a major factor in the treatment of diabetes. The current study was designed to evaluate the neuroprotective effect of CO extract in DN. DN was induced in rats using streptozotocin (STZ) (65 mg/kg, i.p.) after 15 minutes of nicotinamide (NAD; 230 mg/kg, i.p.). Diabetic rats showed significant mechanical, thermal hyperalgesia, and allodynia. Diabetic rats also showed increased oxidative stress parameters and advanced glycation end products (AGEs) formation. Oral treatment was started on 60th day after STZ–NAD administration and continued for the next 30 days, with different doses (150, 300, and 600 mg/kg) of CO extracts (ethanolic and hydroalcoholic) and standard drug gabapentin (30 mg/kg). The results of the study revealed that both extracts reduced hyperglycemia and inhibited the pain response partially via reduction of oxidative stress and AGEs formation in DN rats. Both the extracts reduced the neuropathic pain in diabetic rats at dose dependent manner.
Highlights
Diabetic neuropathy (DN) is well characterized by a range of symptoms and is a universal impediment of diabetes, which affects diabetic subjects across the globe (Berezin, 2016; Kaur et al, 2017; Singh et al, 2013, 2014)
In-vitro antioxidant capacity of CO ethanolic extracts (COEE) and CO hydroalcoholic extracts (COHAE) was assessed by DPPH assay, H2O2 scavenging activity, reducing power assay, and superoxide anion scavenging assay
The effect of COEE and COHAE was compared with ascorbic acid, which was used as a positive control
Summary
Diabetic neuropathy (DN) is well characterized by a range of symptoms and is a universal impediment of diabetes, which affects diabetic subjects across the globe (Berezin, 2016; Kaur et al, 2017; Singh et al, 2013, 2014). DN is a serious complication which results from persistent and chronic hyperglycemic conditions in vascular fluid (Kaur et al, 2017). The fatal effects of chronic and long-lasting hyperglycemia are widely expected to play an essential role in the progression of DN (Kaur et al, 2017; Singh et al, 2013, 2014, 2015).
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