Abstract
Objective To study the therapeutic effect of CpG-ODN,an agonist of Toll-like receptor 9(TLR9),on irradiation injury of bone marrow hematopoietic system in mice.Methods Mice were treated with intraperitoneal injection of CpG-ODN(50 μg each) at 30 min,24 h and 48 h after irradiation.The survival rates of animals were observed after irradiation with different doses,the numbers of white blood cell(WBC) and bone marrow nucleated cells within a certain period of time were observed,the bone marrow was pathologically studied,and the number of endogenous colony forming unit-spleen(endoCFU-S) was counted.Sesults Our results showed that intraperitoneal injection of CpG-ODN significantly improved the survival rate of mice and increased the numbers of peripheral WBC and bone marrow nucleated cells(P0.01);moreover,it also ameliorated the pathological injury of the bone marrow and reduced the death of bone marrow stem cells.Conclusion Intraperitoneal CpG-ODN injection can ameliorate the irradiation injury of bone marrow hematopoietic system in mice.
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