Protective effect of continuous blood purification on lung function in patients with multiple trauma complicated with sepsis

Abstract

Objective To investigate the protection effect of continuous blood purification on pulmonary function in patients with multiple trauma and postoperation concurrent sepsis. Methods Forty-eight cases of multiple trauma patients with postoperative sepsis were selected as the research objects, according to the treatment methods, they were divided into two groups at random; control group(n=24) was given the conventional medical treatment, observation group(n=24)was given the conventional medical and continuous blood purification treatment. The changes of the respiratory function indexes, extravascular lung water (EVLW), pulmonary vascular permeability index (PVPI), inflammation factors before and after treatment in the two groups were compared. Results The fatality rates in observation group was significantly lower than that in control group(12.50% vs. 29.17%, P<0.05); after treatment, the concentration of inflammatory mediators, oxygenation function, respiratory mechanical index, EVLW and PVPI were improved in the two groups; the longer the treatment time, the bigger the improvement, and the observation group was better than the control group (P<0.05). Conclusions Continuous blood purification can reduce the inflammatory mediators in patients with multiple trauma after operation, enhance the pulmonary oxygenation function, improve the pulmonary capillary permeability, and thus play a role in protecting the lung function of patients. Key words: Multiple trauma; Sepsis; Continuous blood purification; Pulmonary function