Abstract
Background: Cadmium (Cd) is a well-known hazardous environmental contaminant. It exerts its toxicity through induction of lipid peroxidation and reduction of cellular antioxidant. Therefore, in this study, we investigated whether cinnamon could protect against Cd toxicity in liver and kidney.Materials and methods: Forty male Wister rats (130-135 gm) were divided randomly into 4 groups/ 10 rats each. Control, cinnamon, cadmium, and Cinn+Cd groups received distilled water, cinnamon extract (200 mg/kg b.wt. orally), cadmium chloride (5 mg/kg b.wt. orally), and Cd plus cinnamon, respectively. Blood, liver, and kidney samples were collected after 8 weeks of treatment. Erythrogram, leukogram, liver and kidney functions, and oxidative status (MDA, CAT, and TAC) were determined.Results and discussion: Cd-treated animals showed significant increases in serum ALT, AST, creatinine, and urea indicating hepatic and renal damage. Cd-induced oxidative stress was observed by marked decease TAC accompanied by increase in MDA which contributed in liver and kidney dysfunction. Co-treatment of Cd with cinnamon has improved the oxidation profile by increasing the TAC and decreasing the lipid peroxidation. Cinnamon ameliorated the toxic effect of Cd, which observed by improvement of liver and kidney functions.Conclusion:Â High antioxidants content of cinnamon could protect the liver and kidney from Cd toxicity.Â
Highlights
Cadmium (Cd), is considered one of the most hazardous metal among other heavy metals
As shown in Table (1), rats administrated Cd showed significant decreases in RBCs count, hemoglobin concentration (Hb) concentration, and HCT comparing to the control group indicating a normocytic normochromic anemia induced by Cd insult
There were no significant changes in hematogical picture between cinnamon and control group
Summary
Cadmium (Cd), is considered one of the most hazardous metal among other heavy metals. It has been reported that Cd induces production of reactive oxygen species (ROS) including superoxide anion, hydrogen peroxide, and hydroxyl radical (Toppo et al 2015). These ROS react with several cellular molecules causing lipid peroxidation, protein oxidation, DNA damage, and induce apoptosis (Stohs et al 2000). Cd-induced oxidative stress was observed by marked decease TAC accompanied by increase in MDA which contributed in liver and kidney dysfunction. Co-treatment of Cd with cinnamon has improved the oxidation profile by increasing the TAC and decreasing the lipid peroxidation. Cinnamon ameliorated the toxic effect of Cd, which observed by improvement of liver and kidney functions. Conclusion: High antioxidants content of cinnamon could protect the liver and kidney from Cd toxicity
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