Abstract
Ipomoea batatas (L.) Lam., Convolvulaceae is widely distributed in Asian areas from tropical to warm-temperature regions. Their tubers are known for their antioxidant, anti-bacterial, anti-diabetic, wound healing, anti-inflammatory, and anti-ulcer activities. The preventive and therapeutic effects of orange-fleshed sweet potato on gastric ulcers have not been investigated. In this study, the carotenoid extract (CE) of orange-fleshed sweet potato was found to protect against gastric ulcers induced by HCl/ethanol in mice. The anti-inflammatory and antioxidant activities of the carotenoid pigment extract were also evaluated as possible evidence of their protective effects. Administration of CE reduced gastric ulcers. Oral administration of CE (100 mg/kg) protected against gastric ulcers by 78.1%, similar to the positive control, sucralfate (77.5%). CE showed potent reducing power and decreased nitric oxide production in a mouse macrophage cell line, RAW 264.7, in a concentration-dependent manner. The production of the inflammatory cytokine interleukin-6 and prostaglandin E2 was also reduced by CE in a dose-dependent manner. The high carotenoid content of orange-fleshed sweet potato could play a role in its protective effect against gastric ulcers. This result suggests the possibility of developing functional products using this nutrient-fortified material.
Highlights
Introduction published maps and institutional affilGastric ulcer, known as stomach ulcer, is the damage to the mucosal lining of the stomach with burning pain in the center of the abdomen [1]
Gastric ulcers were induced using hydrochloric acid and absolute ethanol, which is a popular tool for acute gastric mucosal devastation in a mouse model
With the administration of 0.15 M HCl in ethanol, the major gastric mucosal damage was induced with the hemorrhagic stripe form lesions (70.7 ± 3.2 mm2 ), which were significantly reduced to 15.5 ± 6.5 mm2 in the animals pretreated with carotenoid extract (CE) at the dose of 100 mg/kg with the protective effect of
Summary
Known as stomach ulcer, is the damage to the mucosal lining of the stomach with burning pain in the center of the abdomen [1]. 369,580 people were diagnosed with peptic ulcers (both gastric ulcers and duodenal ulcers) globally in 2020 [3]. Gastric ulcers are positively associated with gastric cancer [4]. It was reported that gastric cancer is the third most common cause of cancer associated death and the fifth highest frequent cancer in the world [5]. South Korea has been reported to have the highest incidence of gastric cancer worldwide [6]. Various kinds of pharmaceutical medications are available for the relief of several gastric disorders, such as proton pump inhibitors, histamine type 2 receptor antagonists, gastric mucosal protectors, iations
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