Protective effect of camel milk on Carbon tetrachloride (CCl4) induced Reno‐toxicity in Rats

Abstract

The kidneys process the blood supplied to it via filtration, reabsorption, secretion and excretion leading to the formation of urine. It is constantly exposed to different drugs and products of metabolism which could be toxic and destructive to renal structures. This study investigated the protective effective of camel milk on carbon tetrachloride induced renotoxicity in wistar rat.Twenty adult wistar rats weighing between 150g and 200g were used in the study to determine the protective effective of camel milk on carbon tetrachloride (CCl4) induced renotoxicity in rats. The rats were divided into 5 groups (A, B, C, D and E) of 4 animals each and were fed with rat feed and water for 30days. Control groups (A and B) were injected intraperitoneally (i/p) with 1ml/kgbw of paraffin oil on the 1st and 2nd days, and in addition group B was fed with camel milk for the remaining days. Groups C and D were injected i/p with CCl4 (1ml/kgbw) for 2 consecutive days and group D fed with camel milk for the remaining period. Group E were fed with camel milk and were injected i/p with CCl4 on the last two daysResults showed a 5.76% decrease in mean body weight of group C significant at p<0.05% while A and B; D and E showed increase in mean body weight of 7.69%, 12.60%, 4.40% and 9.21% respectively. The weight and relative weight of kidneys of Group C was significantly higher (p<0.05) compared with group A and other groups. The sera levels of creatine and urea were significantly raised (p< 0.05) in group C while control and other experimental groups were within normal range. Histologically, there were moderate inflammation, congestion of the glomerulus and tubular necrosis in group C. The renal structures of control, groups B and E appear normal while group D show minimal inflammation.This shows that camel milk protects and ameliorates renal architecture and could serve as a nutritional supplement in renal diseases.This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.