Abstract
Objective: The aim of the current study was to investigate the hepatoprotective, nephroprotective, and cholesterol-lowering activity of aqueous extract of Murraya koenigii (MK) leaves against AlCl3-induced oxidative stress in rats.
 Methods: Wistar albino rats were distributed into six groups (6 each). Group I (control), and Group II administered with distilled water, and aluminum chloride (AlCl3), (40 mg/kg body weight [b.w], oral), respectively. Group III rats were treated with standard Vitamin E (100 mg/kg b.w, p.o) and AlCl3 (40 mg/kg b.w, oral). Group IV, V, and VI received aqueous extract of leaves of Murraya koenigii (AEMK) (100 mg/kg b.w, peroral [p.o], 200 mg/kg b.w, p.o, and 400 mg/kg b.w, p.o), respectively, for a period of 35 days.
 Results: Histopathological examination was observed deformities in hepatic and renal tissues due to aluminum exposure which augment the aforementioned results. Coadministration of AEMK along with Al significantly restored the serum biomarkers to their near-normal levels and has the ability to overcome Al-induced oxidative stress, manifested by a significant reduction in hepatic and renal malondialdehyde level. It increased cellular antioxidant defense, particularly by increasing GPx, glutathione, GR, and catalase levels, preserved normal hepatic and renal histological architecture.
 Conclusion: It could be concluded that AEMK has significant radical scavenging activity and can mop up Al-induced toxicity, suggesting hepatoprotective and nephroprotective potential.
Highlights
Aluminum [1] can accumulate in many tissues, such as kidney, liver, heart, blood, bone, and brain [2]
The induced oxidative stress by aluminum and its salts is responsible for hepatotoxicity [5], nephrotoxicity [6], cardiac toxicity, and reproductive toxicity [7] and neurodegenerative disease and Alzheimer like neurofibrillary tangle formation [8]
The novelty of present research to avoid shortcomings of conventional dosage forms activity on animal study, but the present aqueous extract of leaves of Murraya koenigii (AEMK) leaves are mostly effective against AlCl3-induced oxidative stress in rats
Summary
Aluminum [1] can accumulate in many tissues, such as kidney, liver, heart, blood, bone, and brain [2]. The toxic effect of aluminum was observed to be mediated by reactive oxygen species generation resulting in the oxidative deterioration of cellular lipids, proteins, and DNA and induces changes in the activities of tissue antioxidant enzymes [3] altered gene expression and apoptosis [4]. Numerous active constituents of MK are found to be potent antioxidant. The present research was carried out to investigate the possible nephroprotective and cholesterol-lowering activity of MK against aluminum chloride (AlCl3) -induced intoxication in terms of oxidative stress, biochemical, and histological aspects. The novelty of present research to avoid shortcomings of conventional dosage forms activity on animal study, but the present AEMK leaves are mostly effective against AlCl3-induced oxidative stress in rats
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
