Abstract
Previous investigation has proposed that Antrodia Camphorata possesses beneficial effect mainly on liver protection. To date, the antioxidative effect of Antrodia Camphorata on the tissues of brain, kidney, lung, and liver, however, has not yet clarified. In this current experiment, eighty male Sprague-Dawley rats were randomly divided into control and Antrodia Camphorate-treated subject. Both subjects were intraperitoneally injected with normal saline and Antrodia Camphorata for consecutive 14 days, respectively. On day 15, rats were sacrificed and tissues of brain, kidney, lung, and liver were immediately harvested and homogenate. The malondialdehyde level, an end-product of lipid peroxidation, was measured in different tissues. Experimental result showed that the malondialdehyde levels were significantly (P < 0.05) reduced in all tissues after receiving Antrodia Camphorate as compared with the control subject. Specifically, an obvious decline (12.93%) of the malondialdehyde level was found in the brain as compared to the tissues of kidney, lung, and liver. Accordingly, our present result indicates that Antrodia Camphorate can significantly decline oxidative damage as presented by a reduced malondialdehyde levels in the tissues of brain, kidney, lung, and liver. In addition, it seems likely that the best tissue protective efficacy offered by Antrodia Camphorate in declining oxidative damage is found in the brain tissue.
Highlights
It has been previously proposed that Antrodia Camphorata (AC), one of the traditional Chinese Medicines, possesses beneficial effects in treating a variety of human diseases such as diarrhea, hypertension, abdominal pain, chemical intoxication, and is mainly used for the treatment of liver disease in most of the Asia countries such as Taiwan [1,2,3]
Our present result showed that the mean MDA value in the control and the Antrodia Camphorata-treated subject was 12.30 ± 0.34 and 10.71 ± 0.36 respectively
Our present observation indicated that the MDA level in the control and the Antrodia Camphorata-treated subject was 13.76 ± 0.42 and 13.33 ± 0.14 respectively
Summary
It has been previously proposed that Antrodia Camphorata (AC), one of the traditional Chinese Medicines, possesses beneficial effects in treating a variety of human diseases such as diarrhea, hypertension, abdominal pain, chemical intoxication, and is mainly used for the treatment of liver disease in most of the Asia countries such as Taiwan [1,2,3]. In vivo study has indicated that Antrodia Camphorata can elevate hepatic glutathione-dependent enzymes upon protecting chemical-induced lesion on rat liver and may decline oxidative injury conducted by toxic molecules of hydrogen peroxide [7]. Previous experiment has indicated that cerebral ischemia-induced brain infarction and neurobehavioral disorder can be improved via administration of the traditional Chinese Medicine of Antrodia Camphorata [8,9,10,11,12]. It seems likely to emphasize its beneficial effect here that Antrodia Camphorate may exactly
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