Abstract
BackgroundAntigonon leptopus is a medicinal plant its leaves has not been reported for protective effects against cadmium induced hepatorenal toxicity. Cadmium (Cd) is a non-essential toxic metal used in industrial process, causes severe risk to human health with high levels. It is accumulated primarily in liver and kidney.MethodsMale Wistar albino rats (200-250 g) were divided into 6 groups (n = 6) and had free access to diet and water. Cadmium chloride (5 mg/kg b.w/day) was administered orally for 21 days and methanolic extract of Antigonon leptopus (ALME) was administered to groups of cadmium treated rats at daily doses of 100, 200 and 400 mg/kg b.w;p.o. for 21 days. At the end, liver and kidney markers along with antioxidant parameters are evaluated.ResultsThe results indicated that, administration of cadmium significantly (p < 0.05) increased the levels liver enzymes in serum and bilirubin levels, decreases in total proteins and albumin; in addition to the levels of uric acid, urea and creatinine were increased in the serum. Glutathione (GSH) levels and the enzyme catalase activities were significantly(p < 0.05) decreased while lipid peroxidation was increased in hepatic and renal tissues of cadmium treated rats. The pre-administration of ALME at all the three test doses, alleviated hepatorenal toxicity in cadmium treated rats, used Silymarin (100 mg/kg) as standard. Moreover, ALME treatment was able to reverse the histopathological changes in liver and kidney tissues, and increased the red blood cells, hemoglobin content and decreased prothrombin time and white blood cells.ConclusionAmong all the three test doses, ALME at 200 mg/kg have shown significant antioxidant effect and also exerts beneficial effect against cadmium induced hepatorenal toxicity.
Highlights
Cadmium (Cd) is a common toxic heavy metal in the environment
China; The analytical kits for determination of Aspartate aminotransferase (AST), Alkaline phosphatase (ALP), Alanine aminotransferase (ALT), Total bilirubin (TB), Direct bilirubib (DB), Total proteins (TP), ALB, Urea, Uric acid, Creatinine were purchased from – Merck specialities private limited, Mumbai, India; Trichloro acetic acid (TCA), Thio barbituric acid (TBA) and Cadmium were purchased from Himedia, Mumbai, India; H2O2, NBT – Sigma, Germany; All other chemicals and solvents used were of analytical grade
Phytochemical screening The preliminary phytochemical screening of methanolic extract of Antigonon leptopus leaves exhibited the presence of polyphenols, flavonoids, tannins, glycosides, carbohydrates, steroids and saponins
Summary
Cadmium (Cd) is a common toxic heavy metal in the environment. Cadmium is not biodegradable and its level in the environment is increasing due to industrial activities, and human exposure to Cd is inevitable [1, 2]. The blood cadmium level in human adults is 0.38 μg/L and the minimal risk level is 0.5 μg/kg/day. Antigonon leptopus is a medicinal plant its leaves has not been reported for protective effects against cadmium induced hepatorenal toxicity. Cadmium (Cd) is a non-essential toxic metal used in industrial process, causes severe risk to human health with high levels. It is accumulated primarily in liver and kidney
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
