Abstract
The aim of the study was to evaluate the hepatoprotective effect of ethanolic extract of Annona reticulata Linn (EEAR) leaves using chang liver cell line. Simvastatin was used to induce the hepatotoxicity in the chang liver cell lines. The extract was evaluated for hepatoprotective effect in simvastatin induced hepatotoxicity in chang liver cells. The percentage viability of in the cell line was evaluated by the MTT assay [(3-(4, 5 dimethylthiazole –2 yl)-2, 5 diphenyl tetrazolium bromide) assay. The EEAR treatment significantly improved viability of chang liver cell line which was evident in morphology. The hepatoprotective activity was confirmed by estimating level of Super Oxide mutase enzyme and lipid peroxidation assay. The EEAR significantly increased super oxide mutase enzyme level and decreased lipid peroxidation. Thus the present study ascertains that the leaf extract of Annona reticulata Linn possesses significant hepatoprotective activity.
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