Abstract
Aims: To evaluate the pimpinella anisum supplementation in the prevention of induced osteoporosis in rat model. Methods: Sixty Sprague-Dawley female rats were divided into two groups. Ovariectomised (OVX) group (n = 30) and sham operated group (n =30).Then, each group was further subdivided into control diet (n = 15) and aniseed supplemented diet (n = 15) for 20 weeks. Results: Bone mineral density (BMD) was lower in OVX control vs. sham control (p<0.05). The OVX aniseed supplemented group has higher BMD vs. OVX control group (p<0.05). The urinary excretion of bone resorption marker deoxypyridinoline (DPD) was higher in OVX control vs. sham control group (p<0.05). The OVX aniseed supplemented group has a lower urinary excretion of DPD vs. OVX control group (p<0.05). The increased level of bone formation markers (alkaline phosphatase and osteocalcin) in OVX control group could be prevented by aniseed supplementation. Conclusion: Aniseed can prevent the estrogen deficiency-induced osteoporosis in rats.
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