Abstract
ABSTRACTIncreased oxidative stress has been shown to play an important role in the etiology and pathogenesis of diabetes and its complications. Abelmoschus esculentus (Okra) has been reported to possess many important biological properties. We undertook in vivo studies on male Wistar rats to examine the antioxidative potential of okra in normal and alloxan-treated diabetic rats. Okra extract was administered to control and diabetic rats for 35 consecutive days. Erythrocyte plasma membrane redox system (PMRS) activity (p < 0.05), erythrocytes lipid peroxidation (MDA) (p < 0.01), and advanced oxidation protein products (AOPP) (p < 0.001), increased by 153%, 31%, and 290%, respectively, in response to alloxan treatment, while intracellular reduced glutathione (p < 0.001) and total antioxidant potential of plasma in terms of Ferric reducing ability (FRAP) (p < 0.01) decreased by 75% and 22%, respectively, on alloxan treatment. Okra supplementation provided protection to the rats against alloxan-induced changes. Based on the present results, we hypothesize that okra has strong antioxidative potential and may be used as a dietary supplementation in diabetes for prevention of oxidative stress-mediated complications.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callSimilar Papers
More From: Journal of Dietary Supplements
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
