Protective effect and recovery function of ligustrazine on rats brain injury

Abstract

Objective To study the protective effects and recovery function of ligustrazine on rats brain injury.Methods 50 wistar male rats were randomly divided into 2 groups:A (control group); B (ligustrazine group).group B treated with ligustrazine 10 mg/kg was respectively intraperitoneally injected into the rats 1 hour after SCI,then given ligustrazine at a day interal for 5 days.After the last treatment the each group 5 rats were killed and the levels of SOD,MBA and NO were measured and after last treatment 1,5,10 days motor function of 4 limbs was evaluated and MEP was recorded.Result The levels of SOD in group B was significantly higher than that in group A (P ＜ 0.05) and the level of MDA,NO in group B was significantly lower than that in group A (P ＜ 0.05).Distinct handicap of motor function in 4 limbs presented and amplitudes (Peak-Peak between P1 and N1) of MEP reduced,amplitudes in group B recovered better than that in group A at each measured time (P ＜ 0.05).Conclusion Ligustrazine can decrease the production of free radicals after brain injury and accelerate undee reversion of MEP and promote motor function recovery of braine injury undee restoration of MEP began earlier than that of motor function of 4 limbs. Key words: Ligustrazine; Brain injuries; Superoxide dismutase; Recovery of function