Abstract
Introduction. This study was designed to explore the effect and mechanism of a classic Chinese medicine formula Jiajian Yunvjian (JJYNJ) on cardiac remodeling. Cardiac remodeling after myocardial infarction (MI) model was achieved by coronary artery ligation (CAL). Methodology. When dosed orally once daily, the effects of JJYNJ on hemodynamics, left ventricular weight index (LVWI), heart weight index (HWI), concentration, and gene expression of neuroendocrine factors as well as the histomorphological observation were determined. Results. After 4 weeks, mild cardiac remodeling in CAL group was characterized compared with sham group, but after 4 weeks of treatment of JJYNJ, hemodynamics improved, HWI reduced, and circulating angiotensin II (Ang II), endothelin-1 (ET-1), tumor necrosis factor-α (TNF-α), and hydroxyproline (Hyp) concentrations as well as Ang II receptor type 1 (AT1R) mRNA, transforming growth factor β 1 (TGF-β 1) mRNA, and TNF-α mRNA levels in myocardium were lower than in CAL group. Decreased plasma aldosterone (ALD) concentration, cross-sectional area of cardiomyocyte, collagen volume fraction (CVF), collagen types I and III, perivascular collagen area (PVCA), and upregulated nitric oxide (NO) levels were observed at the same time. Conclusions. These findings suggest that JJYNJ may have a protective and therapeutic function on cardiac remodeling related to MI.
Highlights
This study was designed to explore the effect and mechanism of a classic Chinese medicine formula Jiajian Yunvjian (JJYNJ) on cardiac remodeling
The values of systolic blood pressure (SBP), diastolic blood pressure (DBP), PP, left ventricular systolic pressure (LVSP), and −dp/dtmax were markedly (p < 0.05) lowered in coronary artery ligation (CAL) group compared to the matched sham group, but no changes were showed in heart rate (HR), MABP, +dp/dtmax, and t − dp/dtmax between the two groups
JJYNJ could markedly (p < 0.05) improve SBP level and reduce left ventricular end diastolic pressure (LVEDP) level throughout the experimental period, but there were no significant differences in PP, LVSP, +dp/dtmax, and −dp/dtmax level between CAL and JJYNJ treated CAL groups
Summary
This study was designed to explore the effect and mechanism of a classic Chinese medicine formula Jiajian Yunvjian (JJYNJ) on cardiac remodeling. Cardiac remodeling is an important and fundamental adaptive response to a requirement for increased contractile power. It is a factor intimately associated with chronic heart failure (CHF), and an important cause of increased morbidity and mortality of cardiac diseases [1]. It is regarded as a major risk factor of heart disease. In China, some Chinese physicians succeeded by using JJYNJ in the treatment of infectious and febrile diseases, such as measles, and epidemic hemorrhagic fever
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