Protective and therapeutic effect of Vitex agnus-castus against prostate cancer in rat

doi:10.7324/japs.2017.71219

Abstract

Highlights

Cancer stills a main reason of death, though, research is ongoing for the development of greater effective drugs
Dihydrotestosterone has great ability to conjugate with androgen receptors. 5-α reductase inhibitors stop the function of 5-α reductase leading to increment in the concentrations of testosterone and decreasing in the concentrations of dihydrotestosterone. 5-α reductase inhibitors are used in the management of baldness, prostate hyperplasia and prostate cancer (Blume-Peytavi et al, 2008)
In-vitro anti-prostate cancer using cell line The Cell viability assay was used to determine the cytotoxic effect of Vitex berries crude extract on prostate cancer cell line (PC3) which was assessed by mitochondrial dependent reduction of yellow MTT to purple formazan

Summary

Introduction

Cancer stills a main reason of death, though, research is ongoing for the development of greater effective drugs. Prostate cancer occurs when the prostate gland cells grows uncontrollably which is considered as adenocarcinomas cancer. 5-α reductase enzyme transfers testosterone into dihydrotestosterone. 5-α reductase inhibitors stop the function of 5-α reductase leading to increment in the concentrations of testosterone and decreasing in the concentrations of dihydrotestosterone. 5-α reductase inhibitors are used in the management of baldness, prostate hyperplasia and prostate cancer (Blume-Peytavi et al, 2008). Recent epidemiological studies confirmed the anti-cancer ability of Na+/K+ ATPase inhibitors drugs against prostate, breast, lung cancer or leukemia. The anti-cancer ability of Na+/K+ ATPase inhibitors has confirmed in multiple preclinical assays and have reached early clinical trials (Alevizopoulos et al, 2014)

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