Abstract
The present study aimed to explore the hepatoprotective effects of acidic hydrolysates of polysaccharide extracted from the marine clam M. veneriformis (Ah-MVPS) against ethanol- and CCl4-induced liver damage. Moreover, we also seek to probe the mechanism associated with the liver protection effect of Ah-MVPS. A series of animal and cell experiments were executed to detect suitable serological and histological indicators in hepatic tissues. Ah-MVPS can significantly reduce liver damage by means of an increase in hepatocyte superoxidase dismutase and inhibition of leakages of alanine aminotransferase and aspartate transaminase, as well as through alleviation of malondialdehyde excalation. Ah-MVPS inhibited steatosis and water-like hepatic deterioration in histological examination. They can suppress membrane destruction in boundaries and the collapse of reticular scaffolds of injured mouse hepatocytes and can substantially reduce the inflammatory extent of liver tissue aroused by excessive intake of ethanol or CCl4. In cell assays, Ah-MVPS markedly elevated the viability of L-02 cells exposed to an intoxication of ethanol or H2O2. The beneficial effect of Ah-MVPS might arise, at least in part, because of the amelioration of peroxidation or oxidative stress. Taken together, our findings reveal that Ah-MVPS have potential for development as protective agents to attenuate acute liver injuries.
Highlights
As the largest digestive gland, the liver has the capacity to defend against chemical jeopardy via decomposition or metabolism of exogenous or endogenous toxins that damage the health of the human body (Yang et al, 2013; Uyanoglu et al, 2014)
Our findings demonstrate that Ah-MVPS have promising potentials for development as protective agents for patients who are susceptible to liver diseases
The Ah-MVPS product mainly consisted of numerous oligosaccharide molecules with various degrees of polymerization (DP) because it was derived from MVPS polysaccharide
Summary
As the largest digestive gland, the liver has the capacity to defend against chemical jeopardy via decomposition or metabolism of exogenous or endogenous toxins that damage the health of the human body (Yang et al, 2013; Uyanoglu et al, 2014). Damage to the liver involves many pathological changes, such as hepatocyte inflammation, steatosis, fibrosis, and necrosis, which can be broadly divided into infection and chemical injuries. Natural Polysaccharide Hydrolysates With Liver Protections accompanying acute inflammation, since the hepatocyte is susceptible to many absorbable chemical toxins, and the severity of the pathology is strongly related to type, dose, and period of chemical intakes (Gu and Manautou, 2012). It is essential to find or screen out some compounds that are protective to liver, given the recognized urgency of prevention and treatment of liver diseases. Animals with liver injury induced by CCl4 or ethanol are typical experimental models that have been comprehensively applied in efficacy evaluation and pharmacological investigation of liver-protective drugs, as well as for screening of active compounds (Sun et al, 2013)
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