Protective action of 2,4-dinitrophenol against x-radiation injury. Radioprotective effect of 2,4-dinitrophenol.

Abstract

SummaryThe authors studied the problem of the effect of 2,4-dinitrophenol administered prior to and after irradiation on the development of post-irradiation injury in mice. Estimations revealed that the respiratory metabolism in mice during irradiation was increased after dinitrophenol by 70–80 per cent above rest values before the administration of dinitrophenol, and by as much as 200 per cent above values during sleep in controls. Mice irradiated under these conditions were protected against radiation, as indicated by a highly-significant increase in the number of surviving animals, by a smaller reduction in the number of leucocytes, their more rapid increase in the reparative stage and an earlier onset of regeneration of lymphatic nodules and haemopoietic tissue of the spleen.