Abstract
Protection of small-cell lung cancer circulating tumor cells by cellular fragmentation
Highlights
Small cell lung cancer (SCLC) constitutes approximately 15% of all lung cancers and is characterized by rapid metastasis, universal drug resistance upon recurrence which subsequently leads to a poor prognosis in patients[1]
Dissemination of SCLC appears to be correlated with a high count of circulating tumor cells (CTCs), exceeding the CTC numbers found in carcinomas of breast, colon and prostate by several magnitudes[5]
SCLC CTC cell lines were obtained from blood samples of patients diagnosed with EDSCLC prior to initiation of second-line chemotherapy
Summary
Small cell lung cancer (SCLC) constitutes approximately 15% of all lung cancers and is characterized by rapid metastasis, universal drug resistance upon recurrence which subsequently leads to a poor prognosis in patients[1]. The initial choice of chemotherapy for patients with extended disease (ED)-SCLC includes using platinum-based regimens in combination with etoposide and immune checkpoint inhibitors. This yields high response rates but tumors may invariably relapse and exhibit increased chemoresistanceresulting in a 2-year survival less than 10%[2]. Dissemination of SCLC appears to be correlated with a high count of circulating tumor cells (CTCs), exceeding the CTC numbers found in carcinomas of breast, colon and prostate by several magnitudes[5]. Several studies have reported a higher metastatic potential of CTC aggregates, defined as clusters of different cells[6]
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