Abstract
The aim of the study was to investigate the protective effect provided by immunization with commercial erysipelas vaccines in mice and conventional pigs to challenge with the field strains (serotype 1a) ofErysipelothrix rhusiopathiae. Sequence analysis of surface protective antigen (spaA) gene revealed that the strains were different from those reported previously. A total of 150 mice immunized subcutaneously with live or inactivated vaccines were protected against challenge exposure to one reference and four field strains. Seven conventional pigs immunized intramuscularly with inactivated vaccines developed specific antibodies against the SpaA protein ofE. rhusiopathiaeand were protected against challenge with two field strains. Our study is the first to demonstrate that the commercially available vaccines could protect animals against challenge with the most recently isolated SpaA-type strains ofE. rhusiopathiae.
Highlights
Live and inactivated erysipelas vaccines prepared from Erysipelothrix rhusiopathiae (E. rhusiopathiae) of serotypes 1a and 2, respectively, have been shown to elicit crossprotective immune responses in immunized mice and pigs against challenge with strains of serotypes 1 and 2 (Wood et al 1981; Sawada and Takahashi 1987)
The experiments described in the present study were undertaken to determine whether immunity induced in mice and conventional pigs with the live or inactivated vaccines would withstand challenge exposure with E. rhusiopathiae strains obtained from recent swine erysipelas (SE) outbreaks in Japan
The mice immunized with commercial vaccines were protected against challenge with the virulent Fujisawa strain and the field strains of groups 1 (Kumamoto-S1) and 2 (Gunma- 657, Gunma-649 and Nagano-16)
Summary
Live and inactivated erysipelas vaccines prepared from Erysipelothrix rhusiopathiae (E. rhusiopathiae) of serotypes 1a and 2, respectively, have been shown to elicit crossprotective immune responses in immunized mice and pigs against challenge with strains of serotypes 1 and 2 (Wood et al 1981; Sawada and Takahashi 1987). Several studies have focused on Spa proteins of E. rhusiopathiae responsible for eliciting highly protective antibodies (Imada et al 1999; Ingebritson et al 2010). The experiments described in the present study were undertaken to determine whether immunity induced in mice and conventional pigs with the live or inactivated vaccines would withstand challenge exposure with E. rhusiopathiae strains obtained from recent swine erysipelas (SE) outbreaks in Japan
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