Abstract
The occurrence of carcinoma in areas of vitiligo is extremely rare. Its occurrence has never been recorded at the University of Oklahoma where an average of 200 new skin cancers a year are seen. Some protection against ultraviolet irradiation other than melanin must exist in these patients. Finsen<sup>1</sup>as early as 1900 suggested that the development of hyperkeratosis might afford protection. Lovisatti,<sup>2</sup>Guillaume,<sup>3</sup>and Wirth<sup>4</sup>later demonstrated the increased tolerance to ultraviolet light in vitiliginous and other patients. In 1930, Miescher<sup>5</sup>showed microscopically the hyperkeratosis which occurs upon exposure to ultraviolet light. Comparative measurements of the keratin response in vitiliginous and pigmented areas have never been recorded. Accordingly, the following study was undertaken. <h3>Method</h3> Seven patients with vitiligo were studied. All presented symmetrical depigmentation of the extremities. In each patient, an erythema dose of ultraviolet light from a hot quartz mercury vapor lamp was administered
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