Abstract
Pre-injection of male rats with Zn 2+ (20 μmoles) 24 hr before the administration of Cd 2+ (4 μmoles) partially protects against the changes in weight of the testes that are characteristic of the early stages of Cd 2+-injury. This pre-treatment with Zn 2+ induces the synthesis in the livers of the rats of the Cd 2+-binding protein and, in consequence, Cd 2+ ions accumulate and are thus immobilized more rapidly than in the livers of normal animals. It is probable that this accumulation does not occur simply by replacement of Zn 2+ by Cd 2+ in the pre-synthesized binding protein, but that the synthesis of this protein, when induced by the former cation, is stimulated rapidly and without lag on subsequent administration of the latter.
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