Abstract
Experiments on rats indicate that the fatal renal damage normally produced by acute HgCl2 intoxication is more effectively prevented by thioacetyl containing steroids (e.g., spironolactone, spiroxasone or emdabol) than by inorganic sodium thioacetate. Steroids possesing sulfur in forms other than thioacetyl, as well as steroids devoid of sulfur, did not protect against acute HgCl2 intoxication under our experimental conditions. Among a large series of organic and inorganic sulfur compounds, only dimercaprol (BAL) and Na-thioacetate exhibited any noteworthy antimercurial effect in acute tests. However, dimercaprol possesses considerable inherent toxicity whereas sodium thioacetate, though well tolerated in itself, frequently causes sudden death when given in combination with mercury. In view of these findings the thioacetylated steroids appear to represent a promising class of mercury antidotes.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
