Abstract
Diethyldithiocarbamate provides excellent protection against carbon tetrachloride-induced lethality when administered 1 hr prior to the poison. Lipoperoxidation of liver microsome preparations and the pro-oxidant effect of carbon tetrachloride in vitro are inhibited by low concentrations of diethyldithiocarbamate. On the other hand, NADPH-cytochrome c reductase activity is not affected by addition of diethyldithiocarbamate. These results suggest that the action of the protective agent is not at the level of the flavoprotein of the microsomal electron transport system but elsewhere in the process of lipid peroxidation.
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