Abstract
Recently, it was found that pretreatment with SKF 525-A decreases the concentrations of CCl 4 in the liver and other tissues after oral administration of the halogenated hydrocarbon. This was interpreted as a possible explanation for the protective effect of SKF 525-A on the hepatotoxicity of CCl 4. To test this hypothesis, the relationship between the liver concentration of CCl 4 and its hepatotoxicity has been studied. Rats were given an oral dose of 14CCl 4, which produced liver concentrations similar to those found in rats given twice the dose of 14CCl 4 but pretreated with SKF 525-A. A comparative study of the toxicity of CCl 4 revealed a good correlation between CCl 4 liver concentration and both serum glutamic pyruvic transaminase activity and hepatic triglycerides. There seemed to be no correlation with liver glucose 6-phosphatase activity. It is suggested that the protective effect of SKF 525-A on CCl 4 hepatotoxicity can be explained by a decrease in liver CCl 4 concentration.
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