Abstract
Methotrexate, a well-known cytotoxic chemotherapy, anti-folate, immunosuppressant and effectively treats all major disorders like cancer, psoriasis, refractory rheumatoid arthritis, etc. It is widely and mostly used drug having multitherapy properties and well tolerated, however, its cytotoxic nature leads to many serious side effects, including hepato-renal toxicity, so it is necessary to reduce its side effect and get its benefit. Among all hypothesis, oxidative stress and toxic metabolite are the noticeable cause of toxicity. The present study investigated the protective effects of Zinc alone and its combination with vitamin C and vitamin E against the methotrexate induced hepato-renal toxicity in male albino rats. Zinc is a well-known potent anti-oxidant that scavenges the free radical in tissues. Vitamin C and vitamin E are water soluble and insoluble antioxidant, respectively. In conclusion, the rats treated with zinc alone and its combination with vitamin C and vitamin E had a significant decrease in the level of creatinine, urea, total bilirubin, SGOT, SGPT in blood serum when compared with methotrexate treated rats. Similarly the activity of catalase and reduced glutathione were enhanced and lipid peroxidase was decreased. Histopathology report confirmed the hepato-renal protectivity of Zinc and its combination with vitamin C and vitamin E by restoring the normal architecture of liver and kidney.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
