Abstract
Summary The effects of γ-globulins originating from various animal species on fatal anaphylactic shock induced by passive sensitization have been investigated in guinea pigs and mice. Human and rabbit γ-globulins completely protected guinea pigs against fatal anaphylactic shock when injected in adequate doses before or simultaneously with sensitization. However, γ-globulin was injected after passive sensitization, the protective effect decreased when the interval between sensitization and injection of γ-globulin was increased. A similar effect of human γ-globulin was observed in Haemophilus pertussis-treated and passively sensitized mice. The quantity of γ-globulin required to prevent fatal anaphylaxis was much higher in mice than in guinea pigs. Horse and bovine γ-globulins were ineffective even in very high doses. The significance and the possible mechanism of action of the γ-globulins are discussed.
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