Abstract
Mucosal Immunology The intestinal epithelium is replaced every week. Thus, maintenance of this tissue requires rapid self-renewal driven by intestinal stem cells. This homeostasis is disrupted in a number of settings, including allogeneic bone marrow transplantation. After bone marrow transplantation, allogeneic T cells often attack and kill intestinal cells in an interferon-γ (IFN-γ)–dependent manner. Takashima et al. used in vivo transplant models and in vitro organoid systems to define the targets of IFN-γ in the mouse intestine. They found that IFN-γ directly targets intestinal stem cells. Furthermore, inhibitors of JAK-STAT signaling could be used to protect the intestinal stem cell compartment from T cell–mediated damage. Sci. Immunol. 4 , eaay8556 (2019).
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