Abstract
Finding a compromise: The sequence selectivity of DNA photocleavage by enediyne–, acetylene–, and fulvene–lysine conjugates was investigated by using labeled DNA oligomers. Since the external 32P label was removed by these photocleavers, the label was protected by translocation inside the oligomer (see figure). The selectivity of cleavage is controlled by a compromise between AT selectivity for binding and G selectivity for electron transfer.
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