Abstract
A steady flow of reports suggests that proteasome inhibitor bortezomib promotes tumor cell death by degradation of key proteins. Therefore, bortezomib has been gaining intense attention as an anti-neoplastic agent, being the first proteasome inhibitor drug to be used in multiple myeloma´s treatment. However, new evidences point to the adverse effects of bortezomib leading to the poor outcome in both hematological and solid tumors. Despite its therapeutic effects, deciphering the molecular mechanisms of bortezomib action as well as the mechanism(s) of resistance to bortezomib in cancer remains a problem to be conquered.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
