Abstract
Aging and longevity are two multifactorial biological phenomena whose knowledge at molecular level is still limited. We have studied proteasome function in replicative senescence and cell survival (Mol Aspects Med, in press, 2013). We have observed reduced levels of proteasome content and activities in senescent cells due to the downregulation of the catalytic subunits of the 20S complex (J Biol Chem 278, 28026–28037, 2003). In support, partial inhibition of proteasomes in young cells by specific inhibitors induces premature senescence which is p53 dependent (Aging Cell 7, 717–732, 2008).
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