Abstract
Blood–Brain Barrier In article number 2100812 by Smriti Singh, Agnieszka Morgenroth, and co-workers, Matrix metalloprotease (MMP) sensitive nanogels are synthesized for effective delivery of a radiopharmaceutical ([125I]ITdU) across the blood-brain barrier (BBB). The nanogels show efficient transcytosis across the in vitro model of BBB co-cultured with glioblastoma cells. Once transcytosed, nanogels degrade in an up-regulated MMP2/9 environment of glioblastoma and release the radiopharmaceutical, which gets incorporated into the DNA of tumor cells by thymidine salvage pathway.
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