Abstract
Wheat germ and fish skin usually has not been completely utilized and sometimes may be discarded, thus causing a lot of waste. Here, we aim at exploring the therapeutic anti-inflammatory effects of protease hydrolysates of wheat germ and fish skin on the ulcerative colitis (UC) mice. In the current study, wheat germ protein hydrolysates (WGPH) and fish skin gelatin hydrolysates (FSGH) treated mice had a longer colon than the DSS-induced mice. Moreover, protease hydrolysates reversed DSS-induced gut dysbiosis. Protease hydrolysates were likely to shift the balance of the intestinal flora on inflammation. In summary, these findings suggested that protease hydrolysates might serve as a latent therapy for UC treatment.
Highlights
Ulcerative colitis (UC) is recognized as a type of chronic and recurrent inflammatory bowel disease (IBD) [1]
E continuous improvement in the understanding of UC has evidenced that heredity, environmental factors, dietary habits, immune factors, and gut microbiota are intently related to the occurrence of UC [6, 7]
The interaction between gut microbiota and the host immune system is considered as the major origin of colonic inflammation [8, 9]
Summary
Ulcerative colitis (UC) is recognized as a type of chronic and recurrent inflammatory bowel disease (IBD) [1]. The amount of some ill bacteria (including Bacteroides fragilis, Escherichia coli, and Helicobacter) is flourishing in the UC patients’ intestinal tract, which is markedly higher than that in healthy ones and is probably connected to the incidence of UC [10, 11]. On this basis, researchers have observed the correlation between UC and gut microbiota [12]. Once the intestinal flora is disturbed, it may cause inflammation of the colon [14]
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