Abstract
Background:This study involves the use of a new multifunctional prosthetic mesh for treatment of the perineal hernia without complications. The prosthetic mesh is a hybrid platform of both synthetic and natural materials, mainly consisting of a synthetic commercial polyester fabric (CPF) to deliver the required mechanical integrity. The CPF mesh was coated by a natural biodegradable, biocompatible, and antimicrobial layer of chitosan incorporating phenytoin-loaded pluronic nanomicelles for healing promotion and ciprofloxacin-alginate polyelectrolyte complex-based microparticles as antibacterial agent.Aim:To evaluate the new developed multifunction polyester-based hybridmesh to repair perineal hernia clinical cases in dogs.Methods:The used multifunctional prosthetic mesh is a hybrid of the natural biodegradable, biocompatible, and antimicrobial material used in six cases with perineal hernia.Results:The prosthetic polyester-based hybrid mesh was found very helpful in repairing clinical cases of perineal hernias in six dogs without unwarranted other surgical procedures or complications. The developed mesh proved its feasibility in terms of efficient biocompatibility, stability, sterilizability, and low cost.Conclusion:The prosthetic commercial polyester-based mesh provided the ideal and feasible alternative prosthesis with many advantages.
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