Abstract
Intravesical instillation of Bacillus Calmette-Guerin (BCG) is a treatment to prevent recurrence of superficial urothelial bladder carcinoma. Complications after bladder instillation of BCG have been reported including locally invasive and systemic infections due to dissemination of Mycobacterium bovis from the bladder. We present an uncommon case and literature review of prosthetic joint infection due to M. bovis after intravesical BCG treatment of bladder cancer.
Highlights
The Bacillus Calmette-Guerin (BCG) has been used as intravesical immunotherapy for superficial urothelial bladder carcinoma in preventing its recurrence [1]
We report a case of invasive BCG disease causing prosthetic hip infection in a patient, 19 months after intravesical BCG instillation for superficial bladder carcinoma
In 1921, the BCG vaccine was launched for immunization against tuberculosis in humans
Summary
The Bacillus Calmette-Guerin (BCG) has been used as intravesical immunotherapy for superficial urothelial bladder carcinoma in preventing its recurrence [1]. This modality of treatment is not benign and may have complications. Osteoarticular complications after intravesical BCG instillation can present as infectious and noninfectious, the latter being the most common [3]. An infectious osteoarticular complication of BCG, which implies invasive M. bovis disease, is rare. We report a case of invasive BCG disease causing prosthetic hip infection in a patient, 19 months after intravesical BCG instillation for superficial bladder carcinoma. Other cases of prosthetic joint infection due to BCG after treatment of bladder cancer were reviewed
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