Abstract
The need for replacement of damaged or malfunctioning organs or tissues in the human body has led through intense and innovative research during the past century to the development of materials and devices which are compatible with living tissues. Materials’ compatibility consists in their capability to be accepted by the body when implanted and in contact with other tissues and body fluids. These materials, known as biomaterials, are the fundamental tools for engineering implantable devices dedicated to function in a specific way that substitutes corresponding function of the tissues or organs replaced due to malfunction, in synergism with the surrounding biological environment. Bone fracture healing by the incorporation of plates was known as early as the beginning of the century. Implants to replace heart valves and hip joints have been reported in the early 60s (Park & Lakes, 1992). Among the problems recorded when the first implants were employed were corrosion, mechanical failure and rejection by the body. The latter remains the main problem in the development of novel biomaterials which can be used as implants. Biomaterials now play a major role in replacing or improving the function of every major body system (skeletal, circulatory, nervous, etc.). Commonly employed implants include orthopedic devices such as total knee and hip joint replacements, spinal implants, and bone fixators; cardiac implants such as artificial heart valves and pacemakers; soft tissue implants such as breast implants and injectable collagen for soft tissue augmentation; and dental implants to replace teeth/root systems and bony tissue in the oral cavity. When a man-made material is placed in the human body, tissue reacts to the implant in a variety of ways depending on the material type and function. The mechanism of tissue attachment depends on the tissue response to the implant surface. In general, materials can be placed into three classes that represent the tissue response they elicit: inert, bioresorbable, and bioactive. Inert materials such as titanium and alumina (Al2O3) are nearly chemically inert in the body and exhibit minimal chemical interaction with adjacent tissue. A fibrous tissue capsule will normally form around inert implants. Tissue attachment with inert materials can be through tissue growth into surface irregularities, by bone cement, or by press fitting into a defect. This morphological fixation is not ideal for the long-term stability of permanent implants and often becomes a problem with orthopedic and dental implant applications. Bioresorbable materials, such as tricalcium phosphate and polylactic-
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